Abstract:Chalukou-Tianshuihai area of West Kunlun Mountains in Xinjiang has favorable metallogenic geological conditions and considerable resource potential. Utilizing the newest 1:50 000 geochemical survey data of this area and employing GIS technique, the authors extracted such geochemical information as erosion extent, similarity and contrast value and, on the basis of establishing the geochemical prognostic model for typical lead-zinc deposit and the grade of lead geochemical anomaly credibility, adopted analogue method and planar metallometry to make quantitative prognosis of lead-zinc resources in the study area, thus providing the basis for work deployment of lead-zinc resource exploration and also offering a case study for the deep-going development and application of geochemical exploration data.