The Yinggehai Basin is a hydrocarbon-rich basin, and in the high-temperature and overpressure strata, there exist numerous large-sized exploration targets.Especially in the high-temperature and overpressure field at the medium and deep depths in the Dongfang area, the natural gas exploration is very promising.The target strata of Huangliu Formation in the Dongfang area serve as the major strata, where a thousand billion cubic meters of gas resources have been proved.The accurate pressure prediction and the establishment of the three-dimensional pressure model constitute the cornerstone for the breakthrough in the exploration, and the establishment of the three-dimensional pressure model is based on the three-dimensional lithologic model.The establishment of this lithologic model breaks through the traditional lithologic prediction method in which the seismic impedance threshold value is used as the only means.In this study, the triple constraint trends lithological model is adopted to establish the lithologic model.The verification based on post-drilling pressure-measuring data and pre-drilling predicted three-dimensional pressure model data has proved the effectiveness of the technology of the three-dimensional pressure model, and demonstrated the extensive development vista of this technology.