Time-lapse seism is an important technology for prediction of remaining oil prediction;Nevertheless, due to the need of repeated acquisition of seismic data, the application range of the strictly sense time-lapse seism is subjected to certain restrictions.According to the actual situation of the implementation of the two times of acquisition in high exploration degree oil fields in China, this paper puts forward the non-uniform time-lapse seismic technology.The research train of thought was established with the consistency of the two times of data processing as the basis, mutual constraint processing as the core, and the differential attribute extraction as the purpose.The key technology for elimination of non-reservoir differences between the data was studied, and a non-uniform acquisition of time-lapse seismic processing flow was formed, which maximally eliminates the influence caused by non-uniform acquisition.The technology was applied in YX oilfield, and the result proves that it has a good prospect.