An analysis of geochemical characteristics of the Wangpingxigou large-size lead-zinc deposit in Ruyang of Henan Province reveals that soil geochemical exploration is an effective means in search for lead-zinc deposits. The main economic lead-zinc ore bodies are on the whole confined within the outer margin of the Pb, Zn, Ag and Cu composite anomaly. Where the Pb values and Zn values of the ore-forming parent rocks are 2.5 times and 2 times higher than their respective Tu Hefei's and Venogradov's values of intermediate rocks, they can be regarded as the primary anomalies favorable for ore prospecting.