The Yindongpo gold deposit is a large-size gold deposit hosted in metamorphosed clastic rocks. Based on a geochemical study of the Yindongpo ore deposit, this paper puts forward some useful indicators for further prospecting. They include complexity of the element association with an obvious Au, Ag, Pb, Zn, As, Cd anomaly, an apparent element concentration center with clear element zonation; w(As)/w(Mo)≥4, w(As)+w(Cd)+w(Au)/w(Ni)+w(Co)+w(Mo)≥10, K_k (enriched Clark value) ≥0.5, C_v (Variation coefficient)≥1, regular distribution of striped anomaly as well as stratigraphic and structural control. On the basis of these indicators, ore prognosis was conducted in the periphery of the Yindongpo deposit, covering the area between W4 and W26 exploration lines. The result has been verified by drilling, with new reserves of 11.945 t metals of gold obtained.