Prognosis of ore resources is an indispensable link in scientific exploration. The success rate of ore prognosis depends on people’s knowledge of ore resource regularity, the sufficiency of various sorts of information collected, and the reliability and practicability of criteria f or prognosis established on such a basis. In the application of geophysical and geochemical prospecting to the prognosis of ore resources, we should fully develop arid utilize direct and indirect ore-prospecting information in the data, and employ such methods as mapping-target model analogy, target indicating information statistics and target anomaly inference in practice. In order to push ahead with the prognosis of ore resources, we should utilize the available regional geophysical and geochemical data to the fullest extent and make interpretation on a combined and integrated basis. The systematic performance of large-scale geophysical and geochemical prospecting work, the establishment of geological-geophysical-geochemical models and prognostic criteria, the timely verification of prognostic results and the making of inference, the expansion and renewal of our knowledge and the training of qualified researchers seem to be the mast pressing tasks at present.