To reduce the economic losses caused by pipeline leakage, this paper applies a comprehensive geophysical exploration technology integrating ground-penetrating radar, multi-channel transient surface waves, and resistivity imaging to detect pipeline leakage at a power plant in Huainan, Anhui Province. The results show that the ground-penetrating radar oscillatory signals can reveal the leakage zone, the multi-channel transient surface wave can reflect the leakage severity within the detected area, and the electrical resistivity tomography can present the low-resistance morphology of the leakage zone. Demonstrated by the satisfactory outcomes, this integrated geophysical prospecting method proves to be an effective means to accurately locate the leakage positions for similar pipelines.