Based on discovering the Chelsea East gold deposit in northeastern Mutawatawa of Zimbabwe, the authors put forward the suitable multivariate-information comprehensive prospecting methods for subtropical continental semi-arid climate of South Africa. The methods combine a variety of geological, geophysical, geochemical and engineering means for comprehensive prospecting process on the premise of the study of ore-forming geological characteristics. Practice has proved that the comprehensive prospecting has remarkable economic and prospecting effect besides its rapidness. Based on an integrated analysis of prospecting methods, the authors present a comprehensive prospecting model suitable for gold exploration in this region, which has important guiding significance for gold polymetallic ore prospecting work in this region or even in whole South Africa.