Through the summarization of 75 high density resistivity survey lines and 57 drill holes, the authors studied high density electrical prospecting anomaly of water-bearing structure in karst area of southeast Chongqing. Water-bearing structure in karst area of southeast Chongqing may be divided into three kinds of geological models:corrosion fissure, karst cave and karst conduit, and structural fissure. According to the statistical results of high density electrical prospecting anomaly in karst area of southeast Chongqing, the authors divided them into four groups:low resistance stripe in surface layer, UV type low-resistant anomaly, the paste or cystic low resistance anomaly, and the beaded low resistivity, with each kind of anomaly corresponding to the 1~3 type of water-bearing structure in geological model of the karst area. High density resistivity method is the preferred method for geophysical water exploration in karst areas of southeast Chongqing. The authors summed up the experience of regional exploration and revealed that reasonable interpretation of high density anomaly after the recommendation of drill hole in karst areas can avoid the problem of mudstone filling and increase the well completion ratio.