The high precision airborne geophysical survey can symmetrically obtain high quality multi-parameter geophysical data under the complex terrain conditions at the same time.Two important contents of it are the interpretation of lithostructural mapping and mineral resources prospect.The achievements constitute important geophysical data for basic geological research and regional metallogenic prospective prediction.In this paper,using the new high precision aeromagnetic and airborne gamma energy spectrum data obtained from southeast Hunan,the author gives a systematical description of the process and achievement of the lithostructural mapping and prospecting prediction using the data.The above results can not only directly guide the prospecting work but also serve the relevant geological topics in the future.The comprehensive study shows that the high precision aerial geophysical survey can still play an important role in the area with relatively high geological survey.