The Shiyaogou ore deposit is a large-size molybdenum deposit newly discovered in the East Qinling molybdenum belt. the Shiyaogou ore deposit has proven reserves of more than 100,000 tons Mo, averaging 0.068%. Based on a systematic study of the results obtained from the geophysical and geochemical exploration in the Shiyaogou ore deposit , the authors sum up in detail the three-dimensional distribution regularity of the ore deposit. The data of geophysical and geochemical exploration were used step by step. The discovery of the large-size Shiyaogou Mo deposit not only favorably affects the stable development of Au polymetallic ore-prospecting work but also provides rare and valuable experience in search for more molybdenum resources in the Mo mineralized zone of East Qinling area. Geophysical and geochemical exploration should be further carried out as a necessary means.