The Nannong lead-zinc polymetallic deposit, located in an uplift area between Jiangshan- Shaoxing and Zhenghe-Dapu deep faults in southwestern Zhejiang Province, is one of the typical hydrothermal lead-zinc polymetallic deposits in this area. According to systematical sample collection as well as statistical analysis and calculation of data from drill holes, the authors determined combinational characteristics and axial zonation characteristics of elements as well as variation of geochemical parameters. On such a basis, the possible position of the concealed ore body was predicted. The results provide reliable geochemical evidence in search for deep concealed ore bodies in this area.