The preliminary integrated geophysical and geochemical investigation of polymetallic resources led to the discovery of the Zhitianchong silver ore spot in Huaining County, Anhui Province, which is a silver ore spot discovered for the first time in the Huaining metallogenic area. The mineralized body of this silver ore spot occurs in the middle part of Silurian Gaojiabian Formation and shows stratabound features, belonging to a new species and new horizon. The discovery of the Zhitianchong silver ore spot sheds light on the oreprospecting work in this area. This paper has described mineralization conditions of this silver ore spot and characteristics of composite geophysical and geochemical anomaly and oreprospecting effect, and summarized the exploration model formulated at the stage of preliminary ore resource survey.