Fluvial sandstone commonly constitutes a reservoir in the continental depression. Frequent river diversion, growth of interbedded sandstone and mudstone and fast lateral variation have resulted in interrupted seismic reflection. The reservoir prediction is therefore very difficult. In this paper, precise interpretation of stratigraphic position and isochronous parallelism of strata was made according to actual data. Optimized seismic attributes were extracted, frequency division of thin layers was studied, and river channel distribution in plan was predicted by using the result of frequency division. Simulated sonic inversion using optimized parameters yielded the high precision prediction result. Drilling verification shows that the technology used is very effective.