The extraction of ore-prospecting geochemical information from regional geochemical data is an important subject in geochemical exploration, and the division of geochemical backgrounds and anomalies is the key to the extraction of ore-prospecting geochemical information. Stream sediments are weathering products of rocks and natural material assemblages from the upstream catchment basin, thus having obvious inheritance relationship with rocks of the upstream catchment basin in chemical composition. The content of ore-forming and halo-forming elements is also closely related to major elements. Based on characteristics of stream sediments, the authors adopted the geochemical zoning standardized method to delineate geochemical anomalies. Case studies show that the application of major elements to the division of geochemical zones is effective. The false anomaly in the high background area can be suppressed and the mineralization anomaly in the low background area can be intensified by zoning standardized data processing, thus enhancing the prospecting information. The composite mineralization anomalies are delineated by factor scores of ore-forming and major elements, which can make prominent the ore-induced information.