1:200 000 regional geochemical exploration was carried out in forest-swamp landscape areas, different units have used somewhat different methods and techniques at different working stages, but without obvious effects. Based on tests and studies, the Institute of Geophysical and Geochemical Exploration has formulated a new working method, which holds that in 1:200 000 stream sediment survey the adoption of the sampling grain size grade of -10～＋60 mesh and the sampling density of 1～2 points／4 km² can yield good results. Exemplified by regional geochemical exploration in the 1:200 000 125 km Sheet, the authors made an analysis and comparison between the old and new methods and techniques.