The study of the geochemical exploration methods in special landscape areas of western China has been a hotspot and difficult research point in geochemical prospecting work. In rock-exposed and stream-developed areas we can still use the traditional geochemical stream sediment survey method, but in the covered landscape areas it is not proper to use the conventional methods. At present, with the performance of lots of experiments, it has been proved that the Deep-Penetrating Geochemical Prospecting Method introduced recently can define strategic targets speedily and effectively in the coverage area, thus having wide application prospect. To improve geochemical exploration in special landscape areas of western China, geochemical exploration researchers need to take new methods and new thoughts and systematically develop the research on geochemical methodology, thus finally formulizing a full set of effective geochemical methods suitable for special landscape areas, especially for coverage areas in western China.