Exploration geochemistry is an important method and technique for rapid seeking gold deposits from southwest Guizhou. In last 30 years, many important prospecting clues and targets of micro-disseminated gold deposits, which are difficult to distinguish by naked eyes, were provided according to exploration geochemical gold anomalies. It is suggested that there are predominant in geochemical conditions, more resource perspective and prospecting potential in inner structures of gold geochemical blocks and pedigrees of nested geochemical modeling from gold exploration geochemical history and investigation in southwest Guizhou, and the methods from geology, exploration geophysics, remote sense and et al. are needed to integrate with exploration geochemistry towards more seeking gold deposits and historical tasks.