The authors studied the 1:200000 regional gravity anomalies distributed along the lead-zinc-(copper) ore belt in the Weining-Hezhang-Nayong-Zhijin-Shuicheng area of northwestern Guizhou as well as their corresponding relationships with geological, structural, rock body and geochemical anomalies. The results are helpful to the research on the metallogenic regularity, ore-forming positions and mineralization characteristics of this kind of ore deposits. Some suggestions concerning further ore-prospecting work are put forward in this paper.