In ore-hosting wall rocks, late stage vein rocks and altered rocks of volcanogene hydrothermal ore deposits, the contents of ore-forming elements Pb, Zn and Ag are high, the element associations of ore bodies are complex, the primary anomalies are very developed, and there exists primary zoning. The frontal elements are I, Hg, As, Sb, B and Ba, the near-ore indicator elements are Pb, Zn, Ag, Au, Cd, Mn and Cu, and the rear or underneath indicator elements are Cu, Mo, W and Sn. According to the distribution of the indicator elements and the zoning of the primary anomalies in the ore deposit, the authors put forward geochemical indices for judging the denudation extent and evaluating anomalies of the ore deposit, and set up geochemical ore-prognostic criteria for this kind of ore deposits.