Based on characteristics of minor elements and some major elements inrocks. and ores of the Hongtoushan ore district as well as sulfur isotope distri-bution in the ore deposit, this paper studies the features of primary and sec -ndary anomalies in the ore deposit and puts forward methods for geochemicalreconnaissance and detailed investigation. It is held that the 1:50,000 streamsediment survey can delineate effectively promising prospect areas, and thatthe further detailed investigation can directly delineate orebodies or minerali-zed zones by means of 1:20, 000 or 1:5, 000 soil survey in cooperation with theself-potential method. In prospecting for blind orebodies, the primary halomethod can be used in combination with such techniques as geoelectric che-mistry and soil mercury survey, which might produce obvious effects.