Due to the common coverage of aeolian sand, the effect of conventional geochemical exploration methods is limited in eastern Inner Mongolia, which leads to the inefficiency of concealed ore exploration in spite of superior metallogenic geological condition there. In order to select most effective geochemical exploration methods suitable for eastern Inner Mongolia, the authors studied the effectiveness and practicability of thermal magnetic components and fine-grain survey in the Luokedun lead-zinc deposit. The results are as follows: At orebody location covered by the depth of 90m, two methods all can delineate the anomalies clearly. Thermal magnetic component survey has the advantages of stronger intensity and better continuity, whereas fine-grained soil survey has the convenient and relatively economical advantages. For the overlying thickness of over 200 m, the anomaly of thermal magnetic component survey is more obvious relative to the anomaly detected by fine-grained soil survey, and the anomaly is fairly consistent with the known orebody. Therefore, it is better to choose the method of thermal magnetic component survey to explore concealed ore deposits whose buried depth is over 90m in eastern Inner Mongolia.