This study belongs to the aeromagnetic anomaly verification part of the 1∶ 50,000 high precision aeromagnetic survey project in Tengchong-Yunxian area, Yunnan Province. In order to verify some selected aeromagnetic anomalies in the periphery of the Hetaoping Pb-Zn deposit, the authors carried out geological, geophysical and geochemical survey at the abnormal points. The 2.5D human-computer interaction inversion was used to quantitatively analyze the mineralization potential. The prospecting potential of Fe-Cu-Pb-Zn-polymetallic ore in the periphery of Hetaoping Pb-Zn deposit is proved to be huge, which provides the basis for further prospecting. At the same time, it is proved that after the rapid scanning using aerial geophysical prospecting, researchers should carry out high precision ground geophysical, geochemical and geological techniques and other comprehensive verification methods for positioning, distinguishing and evaluating meaningful anomalies, which could be an economical, fast and efficient air-ground combinational survey method.