The author mainly introduces the application and research of comprehensive geophysical prospecting method in iron and copper poly-metallic ore prospecting target area in nanmentou exploration area of Nanjing,Jiangsu province.By analyzing the gravity-magnetic-electrical abnormal distribution characteristics,to explain and infer the anomalies delineation of gravity low and magnetic values high gravity high and magnetic values high and electrical property.The selection of important anomalies in the area are analyzed combined with geological and geophysical data,and has been verified by drilling holes,and three iron and copper poly-metallic ore prospecting target areas delineated and better prospecting results achieved.