This paper puts forward the suitable sampling particle size for the stream sediments survey in the study area through the test of survey method of stream sediments in northern Huaiyang area. 1:50000 geochemical survey experiment was carried out in the typical ore district by choosing the sample granularity of two kinds of mesh, and the results indicate that the concentration centers of elements coincide with the ore blocks in the ore district. The test results have shown that taking samples of 10~60 mesh coarse fragment media from the surface of valley within each 1000 m² can clearly determine the mineralization anomaly and correctly reflect the shape of the orebody. This result validates the feasibility of sampling granularity and provides guidance for geochemical survey in northern Huaiyang area.