The Da Hinggan Mountains metallogenic belt extends eastwards from arid desert area and the semi arid desert grassland area to the forest swamp areas and mostly belongs to the trouble areas in regional geochemical exploration. Due to the influence of the eolian sand and organic matter, anomaly verification fails to show obvious ore exploration effects. In view of such a situation, the authors put forward the opinion of carrying out 1:500000 geochemical survey in the Da Hinggan Mountains metallogenic belt, with the analysis and demonstration of the necessity and feasibility of this opinion. From such aspects as sampling method, analysis index and metallogenic prediction technology, the authors put forward some assumptions and suggestions. It can be expected that 1:500000 geochemical survey in the Da Hinggan Mountains metallogenic belt can not only realize the macroscopic evaluation of the metallogenic belt but also establish a wider geochemical field closer to the reality for the understanding, assessment and utilization of the 1:200000 regional geochemical exploration data.