The determination of the ore-forming elements is one of the main problems of geochemical anomaly evaluation. Based on previous studies, the authors propose a new method of ore-forming elements determination based on geochemical sampling points, in which anomaly mineralization and anomaly contrast are linked to the concentration coefficient. The lower the concentration coefficient of the element, the higher the anomaly mineralization and the lower the anomaly contrast to ore-forming element. The composition of first ore-forming elements based on the sampling point within a certain range reflects the mineral type. The method was successfully applied to the ore-forming elements analysis of the structure-rock sample from the Dabaoshan copper-lead-zinc-tungsten-molybdenum polymetallic orefield in Guangdong Province. It has important practical value for a detailed analysis of the main ore-forming elements of geochemical anomalies and their distribution, and is suitable for a comparative study of mineralization capabilities of elements with different concentration coefficients.