The study of fine particle total measurement over the Huaniushan Pb-Zn deposit of Gansu Province was conducted. The authors have revealed that major ore-forming elements Pb and Zn show obvious background-anomaly contrast and strong concentration coefficient; in addition, they have positive correlation with Ag, Sb, As, Au, Hg and Cu. There are Pb-Zn-Ag-Au-Sb-As-Cu-Hg geochemical anomalies delineated by this method and the anomalies are located right over the known orebodies, indicating that the geochemical exploration method can be used to effectively locate reliable prospecting targets in Gobi desert terrain.