The prediction of oil-bearing sand of the second member of Eocene Shahejie Formation of Tuo 11 south area faces many problem.First,oil-bearing sand cannot be identified by seismic data because of the small thickness;Second,there exists difference of P-impedance between oil-bearing sand and water-bearing sand.Through the analysis of the geophysical characteristics of oil-bearing sand and water-bearing sand,the authors predicted the spatial distribution characteristics of oil-bearing sand using geostatistical inversion under the constraints of resistivity curve,and also predicted the oil-water interface.Inversion results have confirmed that the oil-water interface is at about the depth of 2237 m,which expands the oil-bearing area determined by early studies and is in good agreement with the results of the new drilling.Geostatistical inversion results have achieved good result in Tuo 11 south area for the first time,which widens the train of thought for the further exploration.