The main minerals in the Yiliu polymetallic ore district are mainly As, Sb, Pb, Zn, Ag, W, Sn, Nb and Ta, the deposit types and the ore-controlling factors are complex and diverse. Recently, by using 1:50000 geochemical stream sediment survey, geochemical soil survey and CSAMT method in this ore district, supergene distribution of elements were found, and many integrated anomalies were delineated. A comprehensive evaluation of all kinds of anomalies shows that the F3 fault has features of ore-passage structure and ore-storage structure, and the area sandwiched between F2 and F3 fault are favorable ore-forming place, whereas the depression parts of biotite granite which have high resistance and multiple sets of fracture intersections are most favorable places for mineralization.