The Yazigou copper-polymetallic deposit is located in Yaziggou area, Mangya Town, Qinghai Province. The development of granodiorite and Tanjianshan Group carbonatite in the area constitutes the main ore-controlling factors to form skarn type copper-polymetallic orebodies. Based on regional geologucal, geophysical and geochemical features, the authors employed the IP intermediate gradient method and the ground high-precision magnetic comprehensive geophysical prospecting method in search for ore deposits in the predicted metallogenic prospect areas. IP intermediate gradient method was used to delineate IP body anomaly, and ground high-precision magnetic measurement was adopted to detect the magnetic features of main geological bodies in the area. Along the important geological sections, IP sounding was used to guide drilling work. Practice indicates that this method is very effective and efficient, and has the reference value for exploration of concealed polymetallic deposits in similar metallogenic regions.