The application of lead and sulfur isotopes to geochemical exploration is still at the stage of exploratory work. In order to further confirm its effect on the exploration of polymetallic deposits,the authors selected a hydrothermal lead and zinc deposit to trace deep orebody by means of Pb isotope and a porphyry copper deposit to detect alteration zoning by means of S isotope and, on such a basis, discussed the δ³⁴S vertical regularity. The test results demonstrate that Pb isotopic composition and V value of three-dimensional topology can predict deep orebodies,the V value increases from the top to the bottom,suggesting the existence of orebodies in the depth. The δ³⁴S mean value in the horizontal direction shows increasing tendency from the high-temperature alteration area to the low-temperature alteration area,and these characteristics can be used to distinguish mineralization and alteration zone. General speaking, the δ³⁴S mean value gradually increases with depth in the vertical direction, there are differences in rock properties and the background values of S isotope in different horizons, and the stacking of the rocks and ore-forming solution may lead to the saltatorial change of the δ³⁴S mean value.