Based on the analysis and interpretation of the application of MRS method to water exploration in permafrost region in combination with an integrated study of drilling data, the authors made detailed explanation and analysis of buried depth and thickness of underground aquifer as well as calculation of outflow rate of groundwater detected by MRS method and obtained satisfactory application result. This paper expounds the unique technical advantages of MRS method in the water exploration of the permafrost region, such as obvious moisture signal reflection, high signal-to-noise ratio and uniqueness of the analytical result, and also points our its weakness in such aspects as determination of lithologic character of the aquifer and the calculation of outflow rate. The results achieved by the authors demonstrate the good prospect of the application of MRS method to water exploration in the permafrost region, and provide some reference experience for further work in this aspect.