In Jindong-Liuqiao area on the southern slope of Dongying Depression, large-area false anomalies emerge from geochemical signals because of strong interference caused by complicated surface conditions. The types of the surface interference were recognized firstly in this area. On such a basis, the geochemical signal was analyzed with Mallat wavelet and the scale 3 continuous sequence reflecting the surface interference was detected and eliminated. The micro-seepage and seepage anomalies for geochemical hydrocarbon exploration of this area were obtained on the basis of the correction of sealing conditions. The anomalies are consistent with faults, traps and hydrocarbon reservoirs already found or the hydrocarbon shows after the interference elimination, which suggests that these anomalies mainly reflect the underground hydrocarbon reservoir information.