The regional geological and geophysical exploration work in Chile remains at relatively low level, the interpretation of mining area geophysical data is insufficient, and the distribution characteristics of ore deposits are not clearly known. The authors made a comprehensive analysis of the geological and geophysical characteristics, and employed the geophysical ground magnetic and electromagnetic measuring method in the X ore district of the first region of Chile. It is held that the relatively high magnetic or weak magnetic low resistivity anomaly zone and its depth and surrounding areas are geophysical anomaly indicators for ore prospecting, and that the structure (shatter zone) should be the focus in further study of the metallogenic regularity. Geophysical exploration methods are of guiding significance in the practical exploration work.