Based on the data of lithogeochemistry and isotope geochemistry, the authors studied geological characteristics,genesis and metallogenic epoch of a certain copper-lead-zinc-barite deposit in Xiangzhou County of Guangxi. Some conclusions have been reached: mineralization of the ore district was controlled by the structural fracturing zone; sulfur in the barite resulted from sea and gypsum-salt of Devonian period; the source beds of copper, lead, zinc and barium were mainly Devonian strata and subordinately deep magma; the ore-bearing solution was hot brine from underground deep cycle water; the metallogenic temperature was about 170℃; the copper-lead-zinc-barite deposit was a mesothermal-epithermal deposit; the metallogenic epoch was early Indosinian-early Yanshanian period. The results obtained by the authors lay the foundation for the further geological exploration.