In order to find an effective means for quick prospecting breakthrough in middle and high mountain areas of West China, which are believed to be the most important mineral exploration areas and replacement bases, China Aero Geophysical Survey and Remote Sensing Center for Land and Resources carried out large-scale aeromagnetic survey in high mountain areas. With high-precision measurements and slow undulating flight in accord with the terrain, qualified raw data were acquired. It was followed by detailed magnetic analysis of rocks, intensive interpretation of anomalies, and fast ground inspection, which made it possible to find a series of metal minerals, thus opening up a new prospect for aeromagnetic survey. According to the test survey and the prospecting effects, the large-scale aeromagnetic method has the advantages of rapidness, high precision, low cost and significant effect in middle and high mountain areas, thus having broad application prospect as well as promotional value in these areas.