The authors carried out the study of geochemical methods for grassland-covered hilly terrains in Dong Ujimqin Banner, Inner Mongolia. The methodological testing of length-grade-horizon and the areal testing of different densities-grades were applied in typical deposits. The conclusions are as follows: The samples at the depth of 20~80 cm can effectively reflect anomalies, and soils at the depth of 40~80 cm are the best sampling media to improve the efficiency. The samples collected 500~3 500 m away from the source area can reflect anomalies. The grade of -120 mesh which is poor in SiO₂ and enriched with metallogenic elements is the effective sampling media for regional and follow-up geochemical survey. A 2 000 km² (at the scale of 1:2 000 000) regional geochemical demonstration reconnaissance was conducted in this landscape, and a comparison with the previous work was carried out. The results indicate that the intensity and boundary of ore-forming element anomalies are clearer and the influence of aeolian sand is minimized in this case. The grade of -120 mesh is the best media for 1:2 000 000 regional geochemical reconnaissance.