To improve the inversion accuracy of reservoirs in the Paleogene strata with limited wells and sedimentary and structural complexity, two key technologies were used in seismic data processing: sparse pulse inversion for primary wave estimation and anisotropic Q-pre-stack depth migration (PSDM). This contributed to improved quality of seismic gathers and imaging. Then, the pre-stack simultaneous inversion method was applied as follows: (1) Stacking velocity and layer-constrained Dix inversion were employed to obtain a low-frequency model of P-wave impedance; (2) Elastic impedance inversion was performed using angle-stacked data and well-calibrated wavelets, yielding far, medium, and near elastic impedance; (3) Initial P- and S-wave impedance, as well as initial density, were obtained through Fatti inversion; (4) Pre-stack simultaneous inversion was performed to obtain the final P- and S-wave impedance and density; (5) Lithology and physical property inversion results were used to predict the reservoir distribution range. This method, driven by three-dimensional seismic data and exhibiting low dependence on logs, can serve as a reference for reservoir prediction under similar geological settings.