The Huaishuping gold deposit is a large quartz vein gold deposit recently discovered in the Xionger Mountain of western Henan Province. The mineralization has the characteristics of multiple periods, and determining the gold metallogenic material association and metallogenic period of this ore deposit would be helpful to further development of the geological prospecting work.The multivariate statistical analysis of geochemical data shows that the enrichment of Au is closely related to the elements of Bi, Ag, the main ore-forming stages of Au is consistent with the As-Ag-Hg combination precipitation phase, the Pb-Zn polymetallic sulfide mineralization stage and the Cu-W-Mo combination precipitation phase. As shown by rock and ore appraisal and field survey, the paragenetic association of minerals is (pyrite, hematite)-marcasite- sphalerite-galena-(chalcopyrite, bornite)-digenite, whereas the wall rock alteration assemblage is potassium feldspar,quartz, biotite, kaolin clay, calcite, dolomite, sericite, chlorite, and epidote. The metallogenic period can be divided into alteration period,hydrothermal period and supergene period, whereas the hydrothermal period can be divided into milky-white quartz vein stage,gray quartz-polymetallic sulfide stage, white quartz vein-pyrite veinlet mineralization stage and quartz-carbonatization stage.