Narigongma area is located in the alpine landscape region of southern Qinghai Province. Great progress has been made in the prospecting for porphyry deposits, and a series of Cu-Mo deposits or ore spots have been found in this area since the performance of the land and resources survey. The conventional integrated geophysical and geochemical methods have played a significant role in prospecting and exploration. Taking the Narigongma Cu-Mo deposit as a typical example and based on summarizing its characteristic criteria in geology, geophysics and geochemistry, the authors established a geological-geophysical-geochemical comprehensive prospecting model for porphyry Cu-Mo deposits. When the model was applied to periphery prospecting, 12 prospecting targets were delineated. In some of the target areas, a few Cu-Mo spots were found by engineering testing and verification.