The studied mining area of Zhejiang province is located in Tongcun of Kaihua-Zitong of Chun'an key exploration area in northwest Zhejiang. It is a favorable block of polymetallic resources, but its previous geophysical and geochemical prospecting work degree is low, with no breakthrough achieved. With the large copper pit mine as an example, the authors used ground high precision magnetic method, soil geochemical survey, CSAMT method and other geophysical and geochemical methods in combination with geological conditions to conduct comprehensive geophysical and geochemical anomaly interpretation and comprehensive evaluation. Drilling verification shows that geophysical and geochemical anomaly can indicate the direction for prospecting and achieve ideal geological effects, and can also play a guiding role in the further geological prospecting work of the neighboring ore blocks.