Located in the middle segment of the Middle and Lower Yangtze metallogenic belt and on the northern margin of Lu-Zong basin, the Xiwan iron-polymetallic ore pre-survey area of the Qingshuitang-Yueshan iron and lead-zinc ore-prospecting target is characterized by low-lying relief, dense network of rivers and thick overburden. In order to solve the problem of prospecting for iron-polymetallic deposits in thick overburden areas, the authors adopted the combined geological and integrated geophysical method to analyze gravity, magnetic and electric anomalies, thus making clear the ore-prospecting target and determining the favorable ore-prospecting position. Drill verification led to the discovery of a lead-zinc deposit at the position of IP anomaly, thus attaining ideal ore-prospecting result.