The landfill leakage pollution has been increasingly serious, and the groundwater pollution has especially attracted more and more attention among researchers. Based on the characteristics of landfill leakage pollution, this paper has studied the application of high-density resistivity method to landfill leakage detection, and proposed a set of work modes and techniques with high-precision. As proved by practical application, the high-density resistivity method for detection of landfill leakage is an effective method deserving popularization.