Despite the existence of abundant ore resources in Dongpo, the proved lead-zinc reserves have begun to be exhausted after years of exploitation. As an assistant means in geological investigation, the method of high ground resolution magnetic measurement was put into practice mainly in potential surveying areas, followed by IP sounding method. High resolution magnetic scanning led to the discovery of 22 magnetic ΔT anomalies mainly along the contact zone of the Qianli Mountain. An analysis of geological conditions and geophysical-geochemical data revealed three remarkable anomaly zones, namely Yeijiwei-Niujiaolong, Meizilong and Shexingping-Tangzhashui. Drilling work in Meizilong area with strong M2 magnetic anomaly disclosed that the thickness of the mineralization is 10.86~32 m, suggesting a large-size skarn deposit with abundant Wu, Sn polymetallic resources. In Niujiaolong area with strong M9 anomaly, the thickness of the lead and zinc mineralized shatter zone reaches 6.4 m. Consequently, a geophysical-geochemical prospecting model in this region was built up, characterized by "two-lows and three-highs". The two-lows are the low apparent resistivity and gravity; whereas the three-highs refer to high ΔT , high apparent polarization and high amount of chemical substances (Pb, Zn, Ag, As,etc) in the earth. As there exists close relation between the Dongpo lead-zinc ore deposit and its surrounding structures, the selection of the survey areas must be based on rocks or underlying structures with strong responses to low gravity and low apparent resistivity. These areas are usually structural shatter zones or skarn zones.