Based on a series of analytical data, this paper studied the isotopic geochemical characteristics of the Lengshuibeigou leadzincsilver ore deposit in Luanchuan County, Henan Province, so as to probe into the variation regularity of elements in the East Qinling leadzincsilver metallogenic system. The oreforming material source, the composition of oreforming hydrothermal fluids and the metallogenic environment of the ore deposit were analyzed. 40Ar39Ar dating of quartz was made, and the result shows that the silverleadzinc bearing quartz veins are products of Late Yanshanian metallogenic process. The achievements obtained are valuable in oreprospecting practice.