Lying in the north margin of Talimu plate, the East Tianshan Mountain has very complicated tectonic background. As there exist remarkable differences in tectonic evolution, magmatic activity, geochemical environment, strata and structural distribution in different parts of the area, geochemical division of the area into subareas should be performed. Four geochemical subareas were distinguished in the study area, i.e., Dananhu islend arc, Xiaorequanzi interarc basin, Kangguer ductile shear deformation belt, and Yamansu back-arc basin. Distribution of Cu, Au high values shows that their ore-forming processes and enrichment are rather complex. The study of these problems has laid a solid foundation for the determination of geochemical backgrounds and thresholds as well as the integrated ore prognosis.