Due to the interferences of several factors, the seismic data in the North Yellow Sea basin are characterized by poor quality, low signal-to-noise ratio and weak ineffective wave energy. In addition, multiple waves of the shallow layer are very strong, characteristics of reflection waves of the medium-deep layer are not clear, and the shallow layer has strong reflective screen. It is therefore necessary to adopt comprehensive interpretation which applies gravimetric and magnetic data in combination with seismic data. Based on analyzing features of the geophysical field and comparing seismic, gravimetric and magnetic data in plane and section, the authors selected key section lines to conduct joint inversion of seismic and gravimetric data and perform comprehensive integrated interpretation. The inconsistency between the interpretative result of gravity and magnetic data and that of seismic data is pointed out. All the achievements made have laid a foundation for further study in the North Yellow Sea basin.