Time, frequency, amplitude and phase differences constitute the main factors affecting the timelapse seismic processing, and elimination of the differences in these four aspects is the key to the unrepeated seismic data processing. The authors analyzed the differences of the construction parameters in two 3D data sets of Yongxin, used the binary corresponding evacuating method to eliminate the differences of field acquisition geometry, eliminated the energy signaltonoise ratio differences between two data sets by targeted denoising technology and energy compensation methods, and used the frequency and phase correction technique to eliminate frequency and phase differences. Based on the four aspects of the mutual constraint processing, the study achieved good results and attained the seismic data processing requirements, thus laying a foundation for subsequent seismic attribute analysis.