As a main and important method in regional geological survey, geochemical survey can not only offer theoretical guidance or inference based geological evidence but also provide direct evidence for mineral resources. The technology was implemented in two periods of specification guidance, i.e., DZ/T 0011-91, DZ/T 0011-2015. In this study, the authors find that there exist some differences in the key links of sample collection, analysis, test and data interpretation in different periods and different working processes by different workers, and hence the results might fail to fully reflect the geochemical information. The authors believe that the real and effective sampling (sample representation), accurate data testing (reliability of results), and scientific interpretation of prediction constitute the key to geochemical survey work.